Research on normal and pathological nervous system development.
Our laboratory’s research focuses primarily on the study of the development of the peripheral nervous system, using mice as the study model. We stand out thanks to our ability to generate genetically modified mice models that are unique in the world. These models are used to improve understanding of the molecular mechanisms responsible for severe congenital malformations such as aganglionic megacolon (Hirschsprung’s disease). Our work should lead to better screening, diagnosis and even treatment of congenital malformation diseases.
Molecular biology, cellular biology, tissue culture, photonic microscopy, 3D fluorescence microscopy
- Life sciences, pharmaceuticals and medical equipment
Specialized labs and equipment
Equipment |
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Leica M205FA microscope |
Leica M125 microscope |
Leica DM2000 microscope |
Thermo HM650V vibration microtome |
Biological safety cabinets |
CO2 incubators |
Additional information
Title |
URL |
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A quantitative cell migration assay for murine enteric neural progenitors. |
http://www.jove.com/video/50709/a-quantitative-cell-migration-assay-for-murine-enteric-neural |
Characterization of a novel transgenic mouse line expressing Cre recombinase under the control of the Cdx2 neural specific enhancer. |
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The developmental genetics of Hirschsprung's disease. |
http://onlinelibrary.wiley.com/doi/10.1111/cge.12032/abstract |
Caudal-related homeobox (Cdx) protein-dependent integration of canonical Wnt signaling on paired-box 3 (Pax3) neural crest enhancer. |
|
A quantitative cell migration assay for murine enteric neural progenitors. | http://www.jove.com/video/50709/a-quantitative-cell-migration-assay-for-murine-enteric-neural |
Characterization of a novel transgenic mouse line expressing Cre recombinase under the control of the Cdx2 neural specific enhancer. | http://onlinelibrary.wiley.com/doi/10.1002/dvg.22421/abstract;jsessionid=7EBF2CDC9460187DCC48D283C1… |
The developmental genetics of Hirschsprung's disease. | http://onlinelibrary.wiley.com/doi/10.1111/cge.12032/abstract |
Caudal-related homeobox (Cdx) protein-dependent integration of canonical Wnt signaling on paired-box 3 (Pax3) neural crest enhancer. | http://www.jbc.org/content/287/20/16623.long |