Our facility supports research in the quantification of xenobiotics and metabolites in biological matrices. We also specialize in determining drug metabolism.
We are experts in bioanalysis with more than 20 years of experience in mass spectrometry and the analysis of drugs in biological matrices. The facility’s staff makes all its expertise in mass spectrometry and bioanalysis directly available to researchers and graduate students for the purposes of designing, carrying out and analyzing experiments. The facility is equipped with state-of-the-art instruments, including three triple quadrupoles (Thermo Quantiva and Thermo Ultra) and a hybrid quadrupole-orbitrap instrument (Thermo Q Exactive Plus) for high-resolution analysis. These instruments are equipped with liquid chromatographic interfaces (HPLC, UHPLC and nano LC). We have recognized expertise in developing, validating and carrying out analyses to specifically identify and quantify xenobiotics and metabolites in biological matrices.
Service personalized to the specific objectives of each research project. Development and validation of innovative and effective analytical methods. Identification and characterization of xenobiotics and metabolites, quantification of xenobiotics and metabolites in biological fluids (blood, plasma, serum, CSF and urine) and more complex matrices (organs). Validation of analytical methods according to the highest quality standards in the industry (ICH and FDA). Sample preparation, extraction and injection, analysis of the results and production of a detailed analytical report.
- Chemical industries
- Life sciences, pharmaceuticals and medical equipment
Specialized labs and equipment
| Equipment | Function |
|---|---|
| Q Exactive Plus | Hybrid Quadrupole-OrbitrapTM Mass Spectrometer, high resolution/accurate mass |
| TSQ Quantiva | Triple quadrupole mass spectrometer |
| TSQ Quantum Ultra | Triple quadrupole mass spectrometer |
| Dionex UltiMate 3000 RSLC | UHPLC chromatography system |
| Dionex UltiMate 3000 RSLCnano | Nano LC chromatography system |
| Shimadzu Prominence UFLC | UFLC chromatography system |
| Shimadzu Prominence UV-VIS, Fluorescence | Detectors |
Additional information
| Title | URL |
|---|---|
| CRCHUM’s scientific facilities | http://crchum.chumontreal.qc.ca/plateformes-et-services |
| CRCHUM Facebook | https://www.facebook.com/CRCHUM/?fref=ts |
| CRCHUM Twitter | https://twitter.com/CRCHUM?lang=fr |