Research on the impact of the digestive system (stomach, small intestine and large intestine) on bioactive compounds.
TIM-1 is the latest, most sophisticated in vitro model ever created. It can be used in combination with bioreactors. TIM-1 simulates digestion conditions in the stomach and small intestine, and the bioreactors simulate the physiological conditions of the large intestine. We can check whether dietary fibre is digested or bioaccessible, evaluate the loss of viability of probiotics during storage, validate the effect of a bioactive molecule on intestinal microflora, and the list goes on. With its high-tech equipment, INAF’s in vitro digestion platform can answer these questions and document the efficiency of different products, with rigorous scientific data. Turnkey contractual agreements are developed to meet our partners’ specific needs.
Digestion and bioaccessibility of dietary fibre, availability and bioaccessibility of nutrients, digestibility of proteins and protein by-products, biomolecule stability and activity, determination of strains with high probiotic potential, probiotic survival rate, bioaccessibility, consumption and degradation of prebiotics, encapsulated molecule release profile, harmlessness of new molecules, effects of bacteria and compounds on pathogen strains, effects of antibacterial molecules on colonic microflora.
- Agriculture, animal science and food
- Consumer durables
- Consumer non-durables
- Life sciences, pharmaceuticals and medical equipment
- Manufacturing and processing
Specialized labs and equipment
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Specialized lab |
Equipment |
Function |
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In vitro digestion platform |
TIM-1 |
Dynamic simulation of digestive conditions in the stomach and small intestine — an essential step in accurately evaluating your product’s effectiveness. |
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Sartorius multiple bioreactors |
Evaluation of a product’s effect on intestinal microflora by means of a dynamic simulation that accurately reproduces the physiological and microbiological conditions of the large intestine. |
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Controlled atmosphere incubator or anaerobic chamber |
Reproduction of the optimal growth conditions for intestinal bacteria and simultaneous growth under a modified atmosphere of a multitude of cultures. |
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Various microbiological analysis equipment |
Quantification of bacterial genera and groups. |
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Analytical platform |
Various chemical analysis equipment |
Quantification of proteins, lipids, carbohydrates, antioxidants, short-chain fatty acids, etc. |
Private and public sector research partners
- University of Alberta
- Fédération des producteurs acéricoles du Québec
- Advitech inc.
- McGill University
- Hofseth Biocare
Additional information
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Title |
URL |
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A model for studying in vitro digestion |
http://www.inaf.ulaval.ca/no_cache/en/services-to-industry/preclinical-t... |
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A video featuring the TIM-1 (produced by the manufacturer) |
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A video featuring the possibilities of the TIM-1 (produced by the manufacturer) |
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A research project conducted with the TIM-1 |
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A research project conducted with the TIM-1 |
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| Published articles (TIM-1) | http://www.inaf.ulaval.ca/services-a-lindustrie/tests-precliniques/digestion-in-vitro/#.WU1MBOvytEZ |
| Published articles (Biorectors) | http://www.inaf.ulaval.ca/services-a-lindustrie/tests-precliniques/digestion-in-vitro/systeme-de-fe… |