In Vitro Digestion Platform

Université Laval, Québec, Québec
What the facility does

Research on the impact of the digestive system (stomach, small intestine and large intestine) on bioactive compounds.

Areas of expertise

TIM-1 is the latest, most sophisticated in vitro model ever created. It can be used in combination with bioreactors. TIM-1 simulates digestion conditions in the stomach and small intestine, and the bioreactors simulate the physiological conditions of the large intestine. We can check whether dietary fibre is digested or bioaccessible, evaluate the loss of viability of probiotics during storage, validate the effect of a bioactive molecule on intestinal microflora, and the list goes on. With its high-tech equipment, INAF’s in vitro digestion platform can answer these questions and document the efficiency of different products, with rigorous scientific data. Turnkey contractual agreements are developed to meet our partners’ specific needs.

Research services

Digestion and bioaccessibility of dietary fibre, availability and bioaccessibility of nutrients, digestibility of proteins and protein by-products, biomolecule stability and activity, determination of strains with high probiotic potential, probiotic survival rate, bioaccessibility, consumption and degradation of prebiotics, encapsulated molecule release profile, harmlessness of new molecules, effects of bacteria and compounds on pathogen strains, effects of antibacterial molecules on colonic microflora.

Sectors of application
  • Agriculture, animal science and food
  • Consumer durables
  • Consumer non-durables
  • Life sciences, pharmaceuticals and medical equipment
  • Manufacturing and processing

Specialized lab



In vitro digestion platform


Dynamic simulation of digestive conditions in the stomach and small intestine — an essential step in accurately evaluating your product’s effectiveness.


Sartorius multiple bioreactors

Evaluation of a product’s effect on intestinal microflora by means of a dynamic simulation that accurately reproduces the physiological and microbiological conditions of the large intestine.


Controlled atmosphere incubator or anaerobic chamber

Reproduction of the optimal growth conditions for intestinal bacteria and simultaneous growth under a modified atmosphere of a multitude of cultures.


Various microbiological analysis equipment

Quantification of bacterial genera and groups.

Analytical platform

Various chemical analysis equipment

Quantification of proteins, lipids, carbohydrates, antioxidants, short-chain fatty acids, etc.

  • University of Alberta
  • Fédération des producteurs acéricoles du Québec
  • Advitech inc.
  • McGill University
  • Hofseth Biocare