BC Cancer Immunotherapy Program

The University of British Columbia, Victoria, British Columbia
What the facility does

Cell engineering and advanced analytics for the immunotherapy of cancer and other health applications

Area(s) of Expertise

The BC Cancer Immunotherapy Program’s Conconi Family Immunotherapy Lab (CFIL) manufactures clinical-grade engineered cell products for the treatment of cancer in the clinical trial setting. For example, we are currently manufacturing Chimeric Antigen Receptor (CAR) T cells for an academic phase I/II clinical trial for leukemia and lymphoma patients. We also provide Mycoplasma testing for T-Cell therapy products on a fee-for-service basis.

Our target discovery and vector development capabilities enable the identification of new target antigens for T-cell therapy, development of novel strategies and tools for T cell engineering, and assessment of these strategies in animal models to generate the necessary preliminary data for future clinical trials.

Our Molecular and Cellular Immunology Core (MCIC) is a full service facility specializing in advanced molecular, genomic and histological methods including multicolour immunohistochemistry and immunofluorescence, automated image analysis, laser capture microdissection, multispectral flow cytometry, and single-cell sequencing.

Research Services

Our group supports academic and industry projects both nationally and internationally, ranging from investigator-driven basic research, to correlative studies for clinical trials, to fee-for-service projects with industrial clients.

Sectors of Application
  • Healthcare and social services
  • Life sciences, pharmaceuticals and medical equipment
  • Manufacturing and processing
  • Professional and technical services (including legal services, architecture, engineering)

Specialized lab

Equipment

Function

CFIL

Panasonic Cell Processing Work Stations (CPWS) (2)

Integrated isolators used for clinical-grade manufacturing of cell products. Each CPWS unit is comprised of a Grade A positive pressure workspace, multiple dockable CO2 incubators, high capacity centrifuge and digital microscope, all housed within a single isolator with an integrated non-viable particle counting and vaporized H2O2 sanitizing capability.

CFIL-Clean Room

CliniMACS Prodigy instruments (4)

Closed devices for clinical-grade manufacturing of CAR-T cells and other cell products

CFIL-Clean Room

Negative pressure compounding aseptic containment isolator

For manipulation of lentivirus stock solutions under BSL-2+ containment

CFIL-Clean Room

Fresenius Kabi Lovo

For cell harvesting/washing within a closed tubing set

CFIL-Clean Room

Terumo TSCD-II Sterile Tubing Welder (2)

Sterile welding devices

CFIL-Clean Room

bioMérieux BacT/Alert 3D Microbial Identification System

Sterility monitoring instrument

CFIL- QC Lab

Endosafe nexgen-PTS

Handheld spectrophotometer for endotoxin testing

CFIL

Beckman Coulter CytoFLEX Flow Cytometer

3 laser/9 colour flow cytometer

CFIL

Luminex FLEXMAP 3D System

HLA (human leukocyte antigen) typing platform

MCIC

Leica LMD7 Laser Microdissection Microscope

Microscopic isolation of samples of interest as large as thick tissue volumes or as small as single living cells

MCIC

Thermo Scientific Microm HM355S Automatic Microtome

Automated microtome

MCIC

PerkinElmer Vectra Polaris Imaging System

Automated quantitative pathology imaging system

MCIC

Leica Aperio VERSA Brightfield, Fluorescence and FISH Digital Pathology Scanner

IHC, ISH and fluorescent tissue-based scanning including multiplex whole slide scanning

MCIC

10X Genomics Chromium Controller

Single cell library construction for genome sequencing

MCIC

Cytek Aurora Cytometers (2)

Spectral flow cytometer

  • BC Cancer Foundation
  • BCRegMed
  • BioCanRx
  • CancerCare Manitoba
  • National Research Council Canada
  • The Ottawa Hospital Research Institute (OHRI)
  • Simon Fraser University
  • Terry Fox Research Institute
  • The University of British Columbia
  • The University Health Network (UHN)

Title

URL

BC Cancer Research Molecular and Cellular Immunology Core (MCIC)

https://www.bccrc.ca/dept/drc/dept/drc/services/molecular-and-cellular-immunology-core

BC Cancer Immunotherapy Program

https://www.bccrc.ca/programs/bc-cancer-immunotherapy-program

BioCanRx Core and Biomanufacturing Facilities

https://biocanrx.com/research/core-facilities