Nuclear Magnetic Resonance Spectroscopy - Centre for Biologics Evaluation

Health Canada, Ottawa, Ontario
What the facility does

Nuclear Magnetic Resonance (NMR) Spectroscopy in the analysis of complex biotherapeutic molecules

Areas of expertise

The work of the laboratory focuses on the development of Nuclear Magnetic Resonance (NMR) based methods for the assessment of novel recombinant protein therapeutics, subsequent entry biologics (biosimilars) and polysaccharide vaccines. Other areas of expertise include the determination of the three-dimensional structure of recombinant protein therapeutics; and the application of NMR techniques to characterize glycoprotein-based therapeutics such as glyco-conjugate vaccines and monoclonal antibodies

Research services

Researching the application of Nuclear Magnetic Resonance spectroscopy to identify and characterize structures of recombinant protein therapeutics and polysaccharide vaccines.

Sectors of application
  • Life sciences, pharmaceuticals and medical equipment
Equipment Function
AVANCE NEO 600 MHz Nuclear Magnetic Resonance spectrometer with 5 mm Triple Resonance CryoprobeFor the investigation structure, dynamics and function of globular proteins
AVANCE HD 700 MHZ Nuclear Magnetic Resonance spectrometer with 5mm and 1.7mm Triple Resonance CryoprobeFor researching and analysing molecular structure
5- and 10-litre bioreactorsFor the production of isotopically labelled proteins
Fast Protein Liquid Chromatography (FPLC) systems (2)For protein purification
  • World Health Organization
  • United States Pharmacopeia
  • US National Institute of Standards and Technology
  • US Food and Drug Administration