The Centre for Applied Genomics (TCAG)

The Hospital for Sick Children, Toronto, Ontario
What the facility does

Genomics and molecular biology research and service provision

Areas of expertise

Established in 1998, The Centre for Applied Genomics (TCAG) is dedicated to conducting and promoting groundbreaking research in genomics, including service and training support for academic, government, and private sector scientists worldwide. We undertake research experimentation and data analysis for more than 800 client researchers each year, drawn from all Canadian provinces and 44 additional countries. Services include informatics, sequencing, genetic analysis, cytogenomics, biobanking, statistical analysis, and comprehensive consultative project design and execution support.

Research services

Sequencing, bioinformatics, genotyping, microarrays, cytogenomics, biobanking, genomic DNA preparation, high performance computing, databasing, statistical analysis, project consultation

Sectors of application
  • Agriculture, animal science and food
  • Healthcare and social services
  • Life sciences, pharmaceuticals and medical equipment

Specialized lab



Sequencing Facility

Illumina NovaSeq 6000 System

High-throughput (“next-generation”) DNA sequencers. Used for a variety of applications including whole-exome and whole-genome sequencing, metagenomics research, sequencing of targeted amplicons and regions, sequencing of immunoprecipitated or methylated DNA, pathogen and small organism genome sequencing, transcriptome sequencing, and others. 

Sequencing Facility

Illumina MiSeq System


Sequencing Facility

PacBio Sequel IIe System


Sequencing Facility

Oxford Nanopore PromethION


Microarray and Genotyping Facility

Affymetrix GeneChip Scanner 3000 7G System

Microarray system for genome-wide or targeted analysis of genetic variability, or gene expression analysis. 

Microarray and Genotyping Facility

Illumina iScan System

Microarray scanner for genome-wide or targeted analysis of genetic variability, or gene expression analysis. 

Cytogenomics Facility

Olympus microscope with ASI software

Microscopes for chromosome analysis, including two-, three-, and four-colour interphase or metaphase FISH, conventional GTG-band karyotyping, analysis of model organism or stem cell chromosomes, and cancer karyotyping.

Cytogenomics Facility

Zeiss microscope with MetaSystems software


Biobanking Facility

Biobanking Equipment

Laminar flow hoods and cell culture incubators for culture and banking of human blood (lymphoblast), fibroblast cells, permanent cell lines, stem cells, and non-human cells for research.

Informatics and Statistical Analysis Facility

Computing cluster and data storage architecture

Used for parallel processing of genome-wide data sets including whole-exome and whole-genome sequence data, whole-genome microarray polymorphism or gene expression data, network/pathway analysis, and statistical genetics and epidemiology analysis.

  • DNA Genotek Inc.
  • DNAstack



TCAG News Articles Archive

Scientists map beaver genome as gift for Canada’s 150th birthday…

Illumina supports Canada’s nationwide COVID-19 genome sequencing initiative…

Breakthrough in autism spectrum research finds genetic ‘wrinkles’ in DNA could be cause…