High-throughput catalyst synthesis and testing, automated experimental protocols
The High-Throughput Experimentation Facility at the Centre for Catalysis Research and Innovation (CCRI) houses high-throughput instrumentation from Unchained Labs, parallel pressure reactors from Parr Instrument Company, and associated analytical tools from Agilent.
Expertise in designing and developing screening-specific protocols, data collection and related analysis. Applications include optimization, lead discovery, and mechanistic insight.
CCRI also houses the Flow Chemistry Core Facility.
Preparation and screening of catalysts in a high-throughput mode, using robotic tools and parallel pressure reactors. Associated anaytical tools that can be accessed by external users include: high-performance liquid chromatography-supercritical fluid chromatography-mass spectrometer (HPLC-SFC-MS ), gas chromatographs-flame ionization detector (GC-FID), ultra-performance liquid chromatography-tandem mass spectrometry (HPLC-MS), gas chromatography-mass spectrometer (GC-MS).
- Chemical industries
- Clean technology
- Education
- Energy (renewable and fossil)
- Forestry and forest-based industries
Specialized labs and equipment
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Specialized Lab |
Euipment |
Function |
|---|---|---|
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High-Throughput Experimentation Lab |
Automated sample processor module located inside a triple drybox |
Generates reaction plates for catalyst preparation or evaluation of catalyzed reactions and the execution of experimental protocols |
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Automated benchtop sample processor |
Generates daughter plates for analysis |
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Screening pressure reactor with gas handling system |
Allows for pressurized gas reactions on multi-well plates |
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Four-position heated orbital shaker |
Allows for pressurized gas reactions on multi-well plates |
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Supercritical fluid/high-performance liquid chromatograph hybrid (SFC/HPLC) with DAD and MS detectors |
Characterization of reaction products |
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Gas chromatographs with flame ionization detectors (2) |
Characterization of reaction products |
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Gas chromatograph integrated with a mass spectrometer detector (GC/MS) |
Characterization of reaction products |
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High-performance liquid chromatograph (HPLC) with DAD (Diode Array Detector) detector |
Characterization of reaction products |
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Eight-solvent purification system piped directly into drybox |
Provides dry solvents for catalyst preparation and testing |
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Karl-Fischer Titrator |
Determines water concentrations in organic solvents |
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Design and execution software and database with dedicated server |
For integrated operation of high-throughput synthesis and evaluation of catalytic reactions. Supports robotic tools, data acquisition and analysis. |
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Variety of chiral columns for GC/SFC/HPLC instruments |
Characterization of asymmetric reaction products |
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Parallel Pressure Reactors |
25 mL Parr Reactors (6), one with auto-sampling and one with manual sampling |
Allows for catalyst testing at higher pressures and in-sequence |
Private and public sector research partners
- BioAmber
- EcoSynthetix
- GreenField Global
- Lonza
- National Research Council (NRC)
- Canada National Institute for Nanotechnology (NINT)
- GreenCentre Canada
- Center for Enabling New Technologies through Catalysis (CENTC USA)
Additional information
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Title |
URL |
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The farmer in the lab |