Manitoba Centre for Proteomics and Systems Biology

The Manitoba Centre for Proteomics and Systems Biology harbors world-class expertise in mass spectrometry (MS), proteomics, chromatography, data analysis, and translational research. The lab has state-of-the-art mass spectrometry equipment and data analysis infrastructure to provide a range of services for researchers from academia, government, and industry. The team works with a wide spectrum of biological materials from human, mouse, other mammals, microbes, and plants. Applications include proteome-wide quantitation of proteins and post-translational modifications to identify regulated proteins and pathways, studying protein-protein interactions, biomarker discovery and validation. The team employs various strategies for quantitative mass spectrometry, such as label free quantitation (data-dependent acquisition and data-independent acquisition), chemical labeling for multiplexing (tandem mass tag, TMT or stable isotope labeling by amino acids in cell culture, SILAC), and targeted MS (parallel-reaction monitoring, PRM). The team has strong expertise in data analysis of omics and multi-omics datasets including the use of machine learning and artificial intelligence. The team can provide support with experimental design, bioinformatics analysis of complex datasets, and meeting publishing guidelines for proteomics datasets.

Interactions are on a cost-recovery basis and can be either strictly service or on a collaborative basis.